In his book Ordering Disorder Khoi Vinh (one of the leading authorities on typographic grid systems in web design) outline the principles that every designer should keep in mind when designing a website on a grid.
The grid has long been an invaluable tool for creating order out of chaos for designers of all kinds—from city planners to architects to typesetters and graphic artists. In recent years, web designers, too, have come to discover the remarkable power that grid-based design can afford in creating intuitive, immersive, and beautiful user experiences.

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